Guillermo Scott Herren was born in Miami, Florida, grew up in Atlanta, Georgia and moved to New York City in 1995.
His father is Catalan and his mother is Irish and Cuban. At an early age his parents encouraged him to play piano and other instruments; his mother "forced" Herren to play a wide variety of instruments, even going so far as to teach him the Suzuki Method in order to "keep him out of trouble". Growing up, Herren's musical tastes branched out and he became interested in hip-hop, punk rock, and electronic music.
He began his career DJing at MJQ, a night club in Atlanta at the time, and then began working in commercial studios producing hip-hop tracks for Dirty South rappers. However, Herren wanted to create his own music and started collecting second-hand instruments and drum machines during this part of his career. He eventually moved to New York City to go to college; there he began realizing his vision that would later become: Prefuse 73.
Herren first released music under the name "Prefuse 73" with 2001's commercially and critically successful Vocal Studies + Uprock Narratives. A year later, a 4-track EP The '92 vs. '02 Collection was released. In 2003, Herren released the full-length album One Word Extinguisher, one of his best known Prefuse 73 albums to date. A companion album, Extinguished: Outtakes was released afterwards showing off some of the production "outtakes" and remixes that were omitted from the initial full-length.
2005 saw the release of Surrounded by Silence, Herren's third album as Prefuse 73. The album featured more collaborations with a variety of musicians, including rappers both underground and mainstream. Herren's next Prefuse 73 release, Security Screenings, was released in 2006; though as long as a full-length, the release was touted as an EP. On August 8, 2007, the fourth Prefuse 73 album, Preparations was announced and it was released on October 15, 2007. The album is sold with a bonus full-length disc titled Interregnums, featuring songs that were more ambient and contemplative than usual Prefuse 73 material.
In June 2008, Herren announced the formation of a new collaborative project, Risil, which includes members of Sunn O))), Hella, School of Seven Bells, Pivot, and others. On June 24, 2009, the supergroup released their debut LP, entitled Non Meters Volume 1. Herren also released a new Savath & Savalas album, entitled La Llama, earlier in March of the same year, and a new Prefuse 73 LP entitled Everything She Touched Turned Ampexian.
In 2009, under the name Diamond Watch Wrists, he and Zach Hill (Death Grips) contributed a cover of a Pivot song to the Warp20 (Recreated) compilation. The group later released the album Ice Capped At Both Ends
In 2015, Herren released three sets under the name Prefuse 73 : two EPs (Forsyth Gardens and Every Color of Darkness) and an album, Rivington Não Rio. on: Temporary Residence LTD.
In May of 2018, Herren will release: "Sacrifices" on: LEX records.